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CD123 Polyclonal Antibody (CAB22111)

SKU:
CAB22111
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
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Description

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CD123 Polyclonal Antibody (CAB22111)

The CD123 Polyclonal Antibody (AB20002) is a valuable tool for research involving CD123, a cell surface marker commonly found on hematopoietic stem cells and leukemic cells. This antibody, produced in rabbits, has high specificity and sensitivity for human samples, making it ideal for immunohistochemistry, flow cytometry, and other applications.CD123, also known as interleukin-3 receptor alpha chain, plays a crucial role in the development and function of hematopoietic cells, making it a key target for research in hematopoiesis, leukemia, and other blood disorders. The CD123 Polyclonal Antibody binds specifically to the CD123 protein, allowing for precise detection and analysis in various cell types and tissues.

With its ability to accurately detect CD123 expression, this antibody is a valuable tool for understanding the role of CD123 in normal hematopoiesis and leukemic transformation. It can help researchers uncover new insights into the mechanisms underlying blood disorders and may lead to the development of novel therapeutic strategies targeting CD123. Whether studying normal hematopoietic cell development or investigating leukemia pathogenesis, the CD123 Polyclonal Antibody is a valuable asset for researchers in the field of hematology.

Product Name:CD123 Polyclonal Antibody
SKU:CAB22111
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-305 of human CD123 (NP_002174.1).
Sequence:KEDP NPPI TNLR MKAK AQQL TWDL NRNV TDIE CVKD ADYS MPAV NNSY CQFG AISL CEVT NYTV RVAN PPFS TWIL FPEN SGKP WAGA ENLT CWIH DVDF LSCS WAVG PGAP ADVQ YDLY LNVA NRRQ QYEC LHYK TDAQ GTRI GCRF DDIS RLSS GSQS SHIL VRGR SAAF GIPC TDKF VVFS QIEI LTPP NMTA KCNK THSF MHWK MRSH FNRK FRYE LQIQ KRMQ PVIT EQVR DRTS FQLL NPGT YTVQ IRAR ERVY EFLS AWST PQRF ECDQ EEGA NTRA WR
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra; IL-3R-alpha
Positive Sample:Mouse spleen
Conjugate:Unconjugated
Cellular Localization:external side of plasma membrane, plasma membrane
Calculated MW:43kDa
Observed MW:70kDa

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.

Purification Method:Affinity purification
Gene ID:3563
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of Mouse spleen, using CD123 Rabbit pAb (CAB22111) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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