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CD11c monoclonal antibody (APC) (AGIM0461)

SKU:
AGIM0461
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
BU15
Conjugation:
APC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD11c monoclonal antibody (APC)
Product Code:AGIM0461
Size:100 µL
Reactivity:Human
Clone:BU15
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P20702
Background:CD11c (p150, ?±X integrin subunit) forms complex with CD18 (??2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other ??2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.
UniProt Protein Function:ITGAX: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; membrane; plasma membrane

Molecular Function:protein binding; receptor activity

Biological Process: cell adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte migration; organ morphogenesis

Disease: Systemic Lupus Erythematosus

NCBI Summary:This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Code:P20702
NCBI GenInfo Identifier:146345441
NCBI Gene ID:3687
NCBI Accession:P20702.3
UniProt Secondary Accession:P20702,Q8IVA6,
UniProt Related Accession:P20702
Molecular Weight:127,829 Da
NCBI Full Name:Integrin alpha-X
NCBI Synonym Full Names:integrin subunit alpha X
NCBI Official Symbol:ITGAX  
NCBI Official Synonym Symbols:CD11C; SLEB6  
NCBI Protein Information:integrin alpha-X
UniProt Protein Name:Integrin alpha-X
UniProt Synonym Protein Names:CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c
UniProt Gene Name:ITGAX  

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