The CD117 Polyclonal Antibody is a valuable tool for research involving CD117, also known as c-kit, a cell surface receptor involved in cell signaling and development. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the CD117 protein, this antibody enables researchers to detect and analyze CD117 expression in various cell types, making it ideal for studies in stem cell research, cancer biology, and hematopoiesis.CD117 is a crucial receptor in various biological processes, including hematopoiesis, melanogenesis, and gametogenesis.
Its dysregulation has been implicated in the development of diseases such as leukemia, gastrointestinal stromal tumors, and mastocytosis. Therefore, understanding the expression and function of CD117 is essential for designing targeted therapies and diagnostic tools for these conditions. The use of the CD117 Polyclonal Antibody in research can provide valuable insights into the role of CD117 in normal physiology and disease pathology, ultimately leading to advancements in personalized medicine and treatment options for patients.
Product Name:
CD117 Polyclonal Antibody
SKU:
CAB21301
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-523 of mouse CD117 (NP_001116205.1).
The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
16590
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using CD117 antibody (CAB21301) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
![PE Anti-Human CD117 Antibody [104D2] (AGEL1778)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/22309/606475/pe-anti-human-cd117-antibody-104d2-agel1778__71407.1707498173.jpg?c=2 "PE Anti-Human CD117 Antibody [104D2] (AGEL1778)")