CD117/c-Kit Monoclonal Antibody (CAB22750)
- SKU:
- CAB22750
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IHC
Description
Product Name: | CD117/c-Kit Monoclonal Antibody |
SKU: | CAB22750 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-520 of human c-Kit (NP_000213.1) |
Sequence: | QPSV SPGE PSPP SIHP GKSD LIVR VGDE IRLL CTDP GFVK WTFE ILDE TNEN KQNE WITE KAEA TNTG KYTC TNKH GLSN SIYV FVRD PAKL FLVD RSLY GKED NDTL VRCP LTDP EVTN YSLK GCQG KPLP KDLR FIPD PKAG IMIK SVKR AYHR LCLH CSVD QEGK SVLS EKFI LKVR PAFK AVPV VSVS KASY LLRE GEEF TVTC TIKD VSSS VYST WKRE NSQT KLQE KYNS WHHG DFNY ERQA TLTI SSAR VNDS GVFM CYAN NTFG SANV TTTL EVVD KGFI NIFP MINT TVFV NDGE NVDL IVEY EAFP KPEH QQWI YMNR TFTD KWED YPKS ENES NIRY VSEL HLTR LKGT EGGT YTFL VSNS DVNA AIAF NVYV NTKP EILT YDRL VNGM LQCV AAGF PEPT IDWY FCPG TEQR CSAS VLPV DVQT LNSS GPPF GKLV VQSS IDSS AFKH NGTV ECKA YNDV GKTS AYFN FAFK GNNK EQIH PHT |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:2000 - 1:20000 IHC-P,1:500 - 1:1000 |
Synonyms: | PBT; SCFR; C-Kit; CD117; MASTC; CD117/c-Kit |
Positive Sample: | HEL |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Single-pass type I membrane protein. |
Calculated MW: | 110kDa |
Observed MW: | 150kDa |
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3815 |
Clone Number: | ARC56007 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |