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CD116 monoclonal antibody (AGIM0002)

SKU:
AGIM0002
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1,k
Clone:
4H1
Conjugation:
Unconjugated
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD116 monoclonal antibody
Product Code:AGIM0002
Size:100 µg in 100 µL
Reactivity:Human
Clone:4H1
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1,k
Host Species:Mouse
Storage:Store at -20°C.
Uniprot:P15509
UniProt Protein Function:CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3

Cellular Component: extracellular region; integral to plasma membrane; intracellular; plasma membrane

Molecular Function:granulocyte colony-stimulating factor binding; granulocyte colony-stimulating factor receptor activity; protein binding; receptor activity

Biological Process: activation of MAPKK activity; axon guidance; cellular protein metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4

NCBI Summary:The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
UniProt Code:P15509
NCBI GenInfo Identifier:121509
NCBI Gene ID:1438
NCBI Accession:P15509.1
UniProt Secondary Accession:P15509,O00207, Q14429, Q14430, Q14431, Q16564, A7J003 A8KAM1, B4DW68, J3JS76, J3JS77,
UniProt Related Accession:P15509
Molecular Weight:31,101 Da
NCBI Full Name:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
NCBI Synonym Full Names:colony stimulating factor 2 receptor alpha subunit
NCBI Official Symbol:CSF2RA  
NCBI Official Synonym Symbols:GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha  
NCBI Protein Information:granulocyte-macrophage colony-stimulating factor receptor subunit alpha
UniProt Protein Name:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
UniProt Synonym Protein Names:CDw116; CD_antigen: CD116
Protein Family:Granulocyte-macrophage colony-stimulating factor receptor
UniProt Gene Name:CSF2RA  
UniProt Entry Name:CSF2R_HUMAN

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