The CD116 GM-CSFR Monoclonal Antibody is a powerful tool for researchers studying the GM-CSFR, a critical receptor involved in the regulation of granulocyte and macrophage production. This monoclonal antibody, produced in mice, demonstrates high specificity and sensitivity for human samples, making it ideal for use in a variety of research applications.The GM-CSFR, also known as CD116, plays a key role in the differentiation and activation of myeloid cells, making it a significant target for studies in immunology, hematopoiesis, and cancer research. By specifically targeting the CD116 protein, this monoclonal antibody allows for accurate detection and analysis of GM-CSFR expression in different cell types, providing valuable insights into its function and potential therapeutic applications.
With its proven performance in Western blot and other research techniques, the CD116 GM-CSFR Monoclonal Antibody is a reliable choice for scientists investigating the role of this important receptor in health and disease. By understanding the mechanisms underlying GM-CSFR signaling, researchers can develop new strategies for manipulating immune responses and combating conditions such as leukemia, autoimmune disorders, and inflammatory diseases.
Product Name:
CD116/GM-CSFRα Monoclonal Antibody
SKU:
CAB23001
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-320 of human CD116/GM-CSFRα (NP_006131.2).
secreted, Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:
27kDa/33kDa/38kDa/44kDa/46kDa/50kDa
Observed MW:
70-80kDa
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
Purification Method:
Affinity purification
Gene ID:
1438
Clone Number:
ARC59284
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD116/GM-CSFRα Rabbit mAb (CAB23001) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
