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CD108 monoclonal antibody (FITC) (AGIM0081)

SKU:
AGIM0081
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgM
Clone:
MEM-150
Conjugation:
FITC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD108 monoclonal antibody (FITC)
Product Code:AGIM0081
Size:500 µL
Reactivity:Human
Clone:MEM-150
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgM
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:O75326
Background:CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes througr its receptors plexin C1 and ??1 integrins.
UniProt Protein Function:SEMA7A: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Belongs to the semaphorin family.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 15q22.3-q23

Cellular Component: external side of plasma membrane; extracellular space; membrane; plasma membrane

Molecular Function:chemorepellent activity; integrin binding; protein binding; semaphorin receptor binding

Biological Process: immune response; integrin-mediated signaling pathway; negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; osteoblast differentiation; positive regulation of axon extension; positive regulation of cell migration; regulation of inflammatory response

Disease: Blood Group, John Milton Hagen System

NCBI Summary:This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
UniProt Code:O75326
NCBI GenInfo Identifier:14548264
NCBI Gene ID:8482
NCBI Accession:O75326.1
UniProt Secondary Accession:O75326,Q1XE81, Q1XE82, Q1XE83, Q1XE84, Q3MIY5, B4DDP7 F5H1S0,
UniProt Related Accession:O75326
Molecular Weight:73,364 Da
NCBI Full Name:Semaphorin-7A
NCBI Synonym Full Names:semaphorin 7A (John Milton Hagen blood group)
NCBI Official Symbol:SEMA7A  
NCBI Official Synonym Symbols:JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1  
NCBI Protein Information:semaphorin-7A
UniProt Protein Name:Semaphorin-7A
UniProt Synonym Protein Names:CDw108; JMH blood group antigen; John-Milton-Hargen human blood group Ag; Semaphorin-K1; Sema K1; Semaphorin-L; Sema L; CD_antigen: CD108
Protein Family:Semaphorin
UniProt Gene Name:SEMA7A  
UniProt Entry Name:SEM7A_HUMAN

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