The CD107b Polyclonal Antibody is a crucial tool for researchers studying CD107b, a protein involved in cytotoxicity and immune cell function. This antibody, produced in rabbits, is highly specific and reacts with human samples, with validated use in Western blotting applications. By binding to CD107b, this antibody enables the detection and analysis of this important protein in various cell types, making it an essential tool for studies in immunology and cancer research.CD107b, also known as Lysosomal Associated Membrane Protein-1 (LAMP-1), plays a key role in cytotoxic granule exocytosis and is a marker for degranulation in cytotoxic T lymphocytes and natural killer cells.
Understanding the function and regulation of CD107b is vital for unraveling the mechanisms of immune cell-mediated killing and developing therapeutic strategies targeting immune responses in various diseases, including infectious diseases and cancer. In summary, the CD107b Polyclonal Antibody is a valuable asset for researchers investigating immune cell function and cytotoxicity mechanisms, providing insights into the role of CD107b in immune response modulation and its potential as a therapeutic target in various disease contexts.
Enables protein domain specific binding activity. Involved in several processes, including autophagosome maturation; protein stabilization; and protein targeting to lysosome involved in chaperone-mediated autophagy. Acts upstream of or within muscle cell cellular homeostasis. Located in late endosome membrane; lysosomal membrane; and phagocytic vesicle membrane. Is integral component of autophagosome membrane. Is expressed in central nervous system; egg cylinder; lung; and retina. Used to study Danon disease. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2).
Purification Method:
Affinity purification
Gene ID:
16784
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD107b Rabbit pAb (CAB23260) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
