The CD105 Rabbit Monoclonal Antibody (CAB19008) is a crucial tool for researchers studying CD105, a cell surface protein involved in angiogenesis and tumor progression. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including immunofluorescence and flow cytometry.CD105, also known as endoglin, is a key marker for endothelial cells and is upregulated in tumor vasculature. Its role in promoting angiogenesis and regulating TGF-beta signaling makes it a promising target for anti-cancer therapies and diagnostics.
The CD105 Rabbit Monoclonal Antibody binds specifically to CD105, allowing for accurate detection and analysis in a range of experimental settings, from basic research to drug development.By utilizing this antibody, researchers can further investigate the mechanisms by which CD105 influences tumor growth, metastasis, and response to therapy. Understanding the biology of CD105 may lead to novel treatment strategies for cancer and other diseases characterized by abnormal angiogenesis.
Product Name:
CD105 Rabbit Monoclonal Antibody
SKU:
CAB19008
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CD105/Endoglin (P17813).
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2022
Clone Number:
ARC0446
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from HUVEC cells, using CD105/Endoglin Rabbit mAb (CAB19008) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
