The CCT8 Polyclonal Antibody (CAB4449) is a crucial tool for research involving CCT8, a subunit of the chaperonin-containing TCP-1 (CCT) complex that assists in protein folding. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CCT8 protein, this antibody enables the detection and analysis of CCT8 in various cell types, making it an essential resource for studies in molecular biology and protein folding mechanisms.CCT8 is an essential component of the CCT complex, which plays a vital role in maintaining protein homeostasis by assisting in the folding of newly synthesized proteins.
Dysregulation of CCT8 has been linked to various diseases, including neurodegenerative disorders and cancer, making it a promising target for research into therapeutic interventions. Understanding the function and regulation of CCT8 is crucial for advancing our knowledge of protein folding pathways and developing potential treatments for diseases associated with protein misfolding.
Product Name:
CCT8 Rabbit Polyclonal Antibody
SKU:
CAB4449
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 248-497 of human CCT8 (NP_001269837.1).
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1.
Purification Method:
Affinity purification
Gene ID:
10694
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CCT8 Rabbit pAb (CAB4449) at 1:7000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
