The CCT6A Polyclonal Antibody (CAB3589) is a valuable tool for researchers studying CCT6A, a protein associated with the chaperonin-containing TCP-1 (CCT) complex involved in protein folding and the assembly of protein complexes. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the CCT6A protein, this antibody enables the detection and analysis of CCT6A in various cell types, making it ideal for investigations in the fields of cell biology, protein folding, and molecular biology.
CCT6A, a subunit of the CCT complex, plays a crucial role in maintaining protein homeostasis and proper protein folding, which is essential for cellular functions and processes. Dysfunction of the CCT complex, including CCT6A, has been implicated in various diseases such as neurodegenerative disorders, cancer, and genetic syndromes. By studying the expression and function of CCT6A, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
CCT6A Rabbit Polyclonal Antibody
SKU:
CAB3589
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 80-250 of human CCT6A (NP_001753.1).
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located.
Purification Method:
Affinity purification
Gene ID:
908
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain, using CCT6A antibody (CAB3589) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
