The CCS Polyclonal Antibody (CAB6803) is a valuable tool for researchers studying CCS, a metalloenzyme involved in copper homeostasis and oxidative stress response. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to the CCS protein, it allows for accurate detection and analysis in a variety of cell types, making it an essential component in studies related to neurodegenerative diseases, oxidative stress, and copper metabolism disorders.
CCS, or copper chaperone for superoxide dismutase, is a crucial enzyme that facilitates the maturation of superoxide dismutase, an important antioxidant enzyme. Dysregulation of CCS function has been linked to conditions such as amyotrophic lateral sclerosis (ALS) and Wilson's disease, highlighting its importance in maintaining cellular health and oxidative balance. Research on CCS is vital for gaining insights into these diseases and developing potential therapeutic interventions that target copper metabolism pathways.
Product Name:
CCS Rabbit Polyclonal Antibody
SKU:
CAB6803
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human CCS (NP_005116.1).
Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
Purification Method:
Affinity purification
Gene ID:
9973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using CCS Rabbit pAb (CAB6803) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
