| UniProt Protein Function: | CCRL2: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: CCR chemokine receptor binding; chemokine receptor bindingBiological Process: inflammatory response |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00421 |
| NCBI GenInfo Identifier: | 108885280 |
| NCBI Gene ID: | 9034 |
| NCBI Accession: | O00421.2 |
| UniProt Secondary Accession: | O00421,O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0 B4DKQ8 |
| UniProt Related Accession: | O00421 |
| Molecular Weight: | 40,952 Da |
| NCBI Full Name: | C-C chemokine receptor-like 2 |
| NCBI Synonym Full Names: | C-C motif chemokine receptor like 2 |
| NCBI Official Symbol: | CCRL2Â Â |
| NCBI Official Synonym Symbols: | HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-BÂ Â |
| NCBI Protein Information: | C-C chemokine receptor-like 2 |
| UniProt Protein Name: | C-C chemokine receptor-like 2 |
| UniProt Synonym Protein Names: | Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCRL2Â Â |
| UniProt Entry Name: | CCRL2_HUMAN |
