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CCRL2 Antibody (PACO00545)

SKU:
PACO00545
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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CCRL2 Antibody (PACO00545)

The CCRL2 Polyclonal Antibody (PACO00545) is a valuable tool for research involving CCRL2, a chemokine receptor known for its role in immune response regulation. This antibody is produced in rabbits and is highly specific for detecting CCRL2 in human samples, making it an ideal choice for Western blot applications.CCRL2, also known as chemokine receptor-like 2, is involved in the recruitment and activation of immune cells, making it a key player in inflammatory processes. Research on CCRL2 has revealed its potential as a therapeutic target for conditions such as inflammatory diseases, cancer, and autoimmune disorders.

By using the CCRL2 Polyclonal Antibody, researchers can accurately detect and analyze CCRL2 expression in various cell types, providing valuable insights into its function and potential clinical relevance. This antibody is a valuable tool for advancing knowledge in immunology and inflammation research, paving the way for the development of new therapies targeting CCRL2.

Antibody Name:CCRL2 Antibody
Antibody SKU:PACO00545
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the Internal region of human CCRL2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CCRL2; CCR11; CCR6; CKRX; CRAM; HCR; C-C chemokine receptor-like 2; Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor
UniProt Protein Function:CCRL2: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: CCR chemokine receptor binding; chemokine receptor bindingBiological Process: inflammatory response
UniProt Protein Details:
NCBI Summary:This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
UniProt Code:O00421
NCBI GenInfo Identifier:108885280
NCBI Gene ID:9034
NCBI Accession:O00421.2
UniProt Secondary Accession:O00421,O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0 B4DKQ8
UniProt Related Accession:O00421
Molecular Weight:40,952 Da
NCBI Full Name:C-C chemokine receptor-like 2
NCBI Synonym Full Names:C-C motif chemokine receptor like 2
NCBI Official Symbol:CCRL2  
NCBI Official Synonym Symbols:HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-B  
NCBI Protein Information:C-C chemokine receptor-like 2
UniProt Protein Name:C-C chemokine receptor-like 2
UniProt Synonym Protein Names:Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor
Protein Family:C-C chemokine receptor
UniProt Gene Name:CCRL2  
UniProt Entry Name:CCRL2_HUMAN

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