The CCR9 Polyclonal Antibody (CAB14848) is an essential tool for researchers studying the CCR9 protein, a chemokine receptor primarily expressed in the small intestine and involved in regulating immune responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CCR9 protein, researchers can effectively detect and analyze its expression in a variety of cell types, making it an ideal choice for studies in immunology and gastrointestinal research.CCR9 is known to play a crucial role in gut immunity and has been associated with a variety of gastrointestinal disorders, making it a valuable target for research on inflammatory bowel diseases, such as Crohn's disease.
Understanding the mechanisms by which CCR9 influences immune responses in the gut can provide valuable insights into the development of targeted therapies for these conditions. The CCR9 Polyclonal Antibody is a reliable tool for investigating the function of CCR9 in health and disease, offering researchers the ability to further explore its potential as a therapeutic target in gastrointestinal disorders.
Product Name:
CCR9 Rabbit Polyclonal Antibody
SKU:
CAB14848
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-369 of human CCR9 (NP_112477.1).
The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10803
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using CCR9 Rabbit pAb (CAB14848) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
