The CCR8 Rabbit Monoclonal Antibody (CAB4288) is specifically designed for research involving CCR8, a chemokine receptor known for its role in regulating immune responses and inflammation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an ideal tool for studying CCR8 expression in various cell types.CCR8 is a key player in recruiting immune cells to sites of inflammation and has been implicated in conditions such as asthma, allergic reactions, and autoimmune diseases. By targeting CCR8 with this monoclonal antibody, researchers can better understand its function and potentially develop new therapies for conditions where CCR8 dysregulation plays a role.
This antibody is validated for use in Western blot applications, allowing for the detection and analysis of CCR8 protein expression. Its high specificity and sensitivity make it a valuable tool for immunology and inflammation research, providing insights into the mechanisms of immune response regulation. Discover the potential of CCR8 with the CCR8 Rabbit Monoclonal Antibody (CAB4288).
Product Name:
CCR8 Rabbit Monoclonal Antibody
SKU:
CAB4288
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-355 of human CCR8 (P51685).
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.
Purification Method:
Affinity purification
Gene ID:
1237
Clone Number:
ARC0956
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CCR8 Rabbit mAb (CAB4288) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
