The CCR7 Polyclonal Antibody (CAB14718) is a valuable tool for researchers studying CCR7, a chemokine receptor known for its role in the migration of immune cells to secondary lymphoid organs. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.CCR7 is essential for the trafficking of dendritic cells and T cells to lymphoid tissues, where they can initiate immune responses. Dysfunction of CCR7 has been implicated in various immune-related disorders, including cancer metastasis and autoimmune diseases.
The CCR7 Polyclonal Antibody enables the detection and analysis of CCR7 protein expression in different cell types, making it a valuable tool for studies in immunology and cancer research.By utilizing the CCR7 Polyclonal Antibody, researchers can gain insights into the mechanisms underlying immune cell trafficking and identify potential targets for therapeutic interventions. Understanding the function of CCR7 is crucial for developing effective treatments for diseases that involve aberrant immune cell migration and activation.
Product Name:
CCR7 Rabbit Polyclonal Antibody
SKU:
CAB14718
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 330-372 of human CCR7 (NP_001829.1).
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1236
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse lung, using CCR7 antibody (CAB14718) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
