The CCR6 Polyclonal Antibody (CAB16206) is a valuable tool for researchers studying CCR6, a chemokine receptor involved in the regulation of immune responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CCR6 protein, this antibody allows for the detection and analysis of CCR6 in various cell types, making it an excellent choice for studies in immunology and inflammatory conditions.
CCR6 is known for its role in the recruitment and activation of immune cells, particularly in the context of inflammatory responses. It is implicated in various diseases, including autoimmune disorders and inflammatory conditions, making it a promising target for therapeutic intervention. Understanding the function of CCR6 is crucial for developing strategies to modulate immune responses and potentially treat associated diseases.
Product Name:
CCR6 Rabbit Polyclonal Antibody
SKU:
CAB16206
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CCR6 (NP_004358.2).
cell surface, external side of plasma membrane, plasma membrane, sperm flagellum, sperm plasma membrane
Calculated MW:
42kDa
Observed MW:
52kDa
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
1235
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from LO2 cells, using CCR6 Rabbit pAb (CAB16206) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
