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Anti-CCR2/CKR2 Antibody (CAB2385)

SKU:
CAB2385
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CCR2
CC-CKR-2
CCR-2
CCR2A
CCR2B
CD192
CKR2
CKR2A
CKR2B
CMKBR2
MCP-1-R
C-C chemokine receptor type 2
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

Product Name:CCR2/CKR2 Rabbit mAb
Product Code:CAB2385
Size:20uL, 50uL, 100uL
Synonyms:CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C chemokine receptor type 2
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CCR2/CKR2.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, U-937, Mouse lung, Rat lung
Immunogen:A synthesized peptide derived from human CCR2/CKR2.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:729230
Uniprot:P41597
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:kDa
Observed MW:42KDa
UniProt Protein Function:CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell soma; integral to plasma membrane; perinuclear region of cytoplasm; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol

Molecular Function:protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: positive regulation of T-helper 1 type immune response; viral reproduction; chemotaxis; elevation of cytosolic calcium ion concentration; response to wounding; dendritic cell chemotaxis; cellular homeostasis; inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; JAK-STAT cascade; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; innate immune response; cellular defense response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; positive regulation of T cell activation; negative regulation of eosinophil degranulation; positive regulation of inflammatory response

NCBI Summary:This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]
UniProt Code:P41597
NCBI GenInfo Identifier:1168965
NCBI Gene ID:729230
NCBI Accession:P41597.1
UniProt Secondary Accession:P41597,Q4VBL2, A0AVQ3, B2RMT0,
UniProt Related Accession:P41597
Molecular Weight:41,064 Da
NCBI Full Name:C-C chemokine receptor type 2
NCBI Synonym Full Names:chemokine (C-C motif) receptor 2
NCBI Official Symbol:CCR2  
NCBI Official Synonym Symbols:CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2  
NCBI Protein Information:C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
UniProt Protein Name:C-C chemokine receptor type 2
UniProt Synonym Protein Names:Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD_antigen: CD192
Protein Family:C-C chemokine receptor
UniProt Gene Name:CCR2  
UniProt Entry Name:CCR2_HUMAN

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