The CCR2 Polyclonal Antibody (CAB2855) is a valuable tool for researchers studying CCR2, a chemokine receptor involved in the recruitment and activation of inflammatory cells. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the CCR2 protein, this antibody allows for the detection and analysis of CCR2 in a variety of cell types, making it a versatile tool for studies in immunology and inflammation research.CCR2 is known for its role in regulating the migration of immune cells to sites of inflammation, making it a key player in the immune response to infection and injury. Dysregulation of CCR2 signaling has been linked to a variety of inflammatory conditions, including autoimmune diseases and cardiovascular disorders.
By targeting CCR2, researchers can gain valuable insights into the mechanisms underlying these diseases and develop novel therapeutic strategies to modulate immune cell recruitment and activation.Overall, the CCR2 Polyclonal Antibody (CAB2855) is a powerful tool for investigating the role of CCR2 in immune responses and inflammatory processes. Its high specificity and reliability make it a valuable asset for researchers looking to unravel the complexities of immune regulation and develop targeted therapies for a range of inflammatory diseases.
Product Name:
CCR2 Rabbit Polyclonal Antibody
SKU:
CAB2855
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human CCR2 (NP_001116513.2).
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.
Purification Method:
Affinity purification
Gene ID:
729230
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of RAW264.7 cells, using CCR2 antibody (CAB2855) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
