The CCR2 Polyclonal Antibody (PACO02278) is a valuable tool for researchers studying CCR2, a chemokine receptor essential in the regulation of immune responses and inflammation. This antibody, developed using rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By targeting the CCR2 protein, researchers are able to detect and analyze its expression in various cell types, making it ideal for studies in immunology, inflammation, and cancer research.CCR2 is a key player in the recruitment of monocytes and macrophages to sites of inflammation, making it a promising target for therapeutic interventions in diseases such as cancer, atherosclerosis, and autoimmune disorders.
By studying the function of CCR2, researchers can gain valuable insights into the underlying mechanisms of these diseases and develop novel strategies for treatment.Overall, the CCR2 Polyclonal Antibody (PACO02278) is a valuable tool for researchers interested in exploring the role of CCR2 in immune regulation and inflammation, offering insights that could lead to the development of new therapies for a range of diseases.
Antibody Name:
CCR2 Antibody
Antibody SKU:
PACO02278
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human CKR-2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CCR2; CMKBR2; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD antigen CD192
UniProt Protein Function:
CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integralCellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membraneMolecular Function: G-protein coupled receptor activity; signal transducer activity; protein binding; C-C chemokine receptor activity; cytokine binding; chemokine receptor activityBiological Process: positive regulation of T-helper 1 type immune response; sensory perception of pain; chemotaxis; signal transduction; regulation of cell migration; monocyte chemotaxis; hemopoiesis; angiogenesis; cellular homeostasis; inflammatory response; healing during inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; humoral immune response; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; cellular defense response; positive regulation of alpha-beta T cell proliferation; immune response; blood vessel remodeling; positive regulation of T cell activation; negative regulation of eosinophil degranulation; positive regulation of T-helper 1 cell differentiation; apoptotic cell clearance; positive regulation of inflammatory response
