The CCR1 Polyclonal Antibody (CAB18341) is specifically designed for research involving CCR1, a chemokine receptor known to play a role in immune cell migration and inflammation. This rabbit polyclonal antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the CCR1 protein, this antibody enables the detection and analysis of CCR1 in various cell types, making it an invaluable tool for studies in immunology, inflammation, and cancer research.
CCR1 is a key player in the chemotaxis of immune cells, particularly in inflammatory responses. Its involvement in immune cell recruitment makes it a potential target for research into various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Understanding the functions and regulation of CCR1 is essential for developing therapeutic strategies that target the chemokine receptor pathway for the treatment of these diseases.
Product Name:
CCR1 Rabbit Polyclonal Antibody
SKU:
CAB18341
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 255-354 of human CCR1 (NP_001286.1).
cytoplasm, external side of plasma membrane, plasma membrane
Calculated MW:
41kDa
Observed MW:
37kDa
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.
Purification Method:
Affinity purification
Gene ID:
1230
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from RPMI 8226 cells, using CCR1 Rabbit pAb (CAB18341) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
