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CCR1 Rabbit Polyclonal Antibody (CAB18341)

SKU:
CAB18341
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:CCR1 Rabbit Polyclonal Antibody
SKU:CAB18341
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 255-354 of human CCR1 (NP_001286.1).
Sequence:YNLT ILIS VFQD FLFT HECE QSRH LDLA VQVT EVIA YTHC CVNP VIYA FVGE RFRK YLRQ LFHR RVAV HLVK WLPF LSVD RLER VSST SPST GEHE LSAG
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1; CCR1
Positive Sample:RPMI 8226
Cellular Localization:cytoplasm, external side of plasma membrane, plasma membrane
Calculated MW:41kDa
Observed MW:37kDa

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

Purification Method:Affinity purification
Gene ID:1230
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from RPMI 8226 cells, using CCR1 Rabbit pAb (CAB18341) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.

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