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CCNF Antibody (PACO14313)

SKU:
PACO14313
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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CCNF Antibody (PACO14313)

The CCNF Polyclonal Antibody (PAC014313) is a valuable tool for researchers studying the CCNF protein, which plays a crucial role in cell cycle regulation and cell division. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the CCNF protein, this antibody facilitates the detection and analysis of CCNF in various cell types, making it an essential component of studies in cell biology and cancer research.

CCNF, also known as cyclin F, is a key player in the degradation of cell cycle regulators, thereby influencing the progression of the cell cycle. Dysregulation of CCNF has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. By delving into the functions of CCNF, researchers can gain valuable insights into the mechanisms underlying tumorigenesis and potentially identify novel therapeutic strategies for combating cancer.

Antibody Name:CCNF Antibody (PACO14313)
Antibody SKU:PACO14313
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:Human
Immunogen:Fusion protein of human CCNF
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14313(CCNF Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid, motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.
Synonyms:cyclin F
UniProt Protein Function:CCNF: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Belongs to the cyclin family. Cyclin AB subfamily.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 16p13.3Cellular Component: centriole; SCF ubiquitin ligase complex; nucleusMolecular Function: protein bindingBiological Process: mitosis; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; re-entry into mitotic cell cycle; cell division; protein ubiquitination; placenta development
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
UniProt Code:P41002
NCBI GenInfo Identifier:118572588
NCBI Gene ID:899
NCBI Accession:NP_001752.2
UniProt Secondary Accession:P41002,Q96EG9, B2R8H3
UniProt Related Accession:P41002
Molecular Weight:87,640 Da
NCBI Full Name:cyclin-F
NCBI Synonym Full Names:cyclin F
NCBI Official Symbol:CCNF  
NCBI Official Synonym Symbols:FBX1; FBXO1  
NCBI Protein Information:cyclin-F; F-box only protein 1; G2/mitotic-specific cyclin-F
UniProt Protein Name:Cyclin-F
UniProt Synonym Protein Names:F-box only protein 1
Protein Family:Cyclin
UniProt Gene Name:CCNF  
UniProt Entry Name:CCNF_HUMAN
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