The CCNE2 Polyclonal Antibody (CAB7032) is a valuable tool for researchers studying CCNE2, a critical protein involved in cell cycle regulation and cancer development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CCNE2 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential component for studies in oncology and cell biology.CCNE2, also known as Cyclin E2, plays a key role in driving cell cycle progression and promoting cell proliferation. Its dysregulation has been implicated in the development and progression of various cancers, making it a promising therapeutic target for cancer treatment.
By studying the function of CCNE2, researchers can gain insights into the mechanisms underlying tumor growth and potentially identify novel strategies for cancer therapy.The CCNE2 Polyclonal Antibody is a valuable resource for researchers seeking to understand the role of CCNE2 in cancer biology and explore its potential as a target for anti-cancer therapy. Its high specificity and sensitivity make it an indispensable tool for investigating the molecular mechanisms of cancer development and identifying new therapeutic avenues in the fight against cancer.
Product Name:
Cyclin E2 Rabbit Polyclonal Antibody
SKU:
CAB7032
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 255-404 of human Cyclin E2 (NP_477097.1).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.
Purification Method:
Affinity purification
Gene ID:
9134
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Jurkat cells, using Cyclin E2 antibody (CAB7032).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
