The CCNE2 Polyclonal Antibody (CAB4272) is specifically designed for researchers studying CCNE2, a key protein involved in cell cycle regulation and cancer development. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CCNE2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential tool for studies in cancer biology and molecular genetics.CCNE2, also known as cyclin E2, is a critical regulator of the cell cycle, promoting cell proliferation and progression through various stages.
Dysregulation of CCNE2 has been linked to oncogenesis and tumor growth, making it a promising target for cancer research and therapeutic development. By investigating the role of CCNE2 in cancer pathology, researchers can gain valuable insights into potential treatment strategies and diagnostic markers for various types of cancer. Overall, the CCNE2 Polyclonal Antibody is a valuable resource for scientists looking to explore the complex mechanisms of cell cycle control and cancer progression, ultimately contributing to advancements in our understanding of cancer biology and the development of targeted therapies.
Product Name:
Cyclin E2 Rabbit Polyclonal Antibody
SKU:
CAB4272
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 255-404 of human Cyclin E2 (NP_477097.1).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.
Purification Method:
Affinity purification
Gene ID:
9134
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cyclin E2 Rabbit pAb (CAB4272) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
