Cyclin D2 Rabbit Polyclonal Antibody (CAB1773)
- SKU:
- CAB1773
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | Cyclin D2 Rabbit Polyclonal Antibody |
SKU: | CAB1773 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-289 of human Cyclin D2 (NP_001750.1). |
Sequence: | MELL CHEV DPVR RAVR DRNL LRDD RVLQ NLLT IEER YLPQ CSYF KCVQ KDIQ PYMR RMVA TWML EVCE EQKC EEEV FPLA MNYL DRFL AGVP TPKS HLQL LGAV CMFL ASKL KETS PLTA EKLC IYTD NSIK PQEL LEWE LVVL GKLK WNLA AVTP HDFI EHIL RKLP QQRE KLSL IRKH AQTF IALC ATDF KFAM YPPS MIAT GSVG AAIC GLQQ DEEV SSLT CDAL TELL AKIT NTDV DCLK ACQE QIEA VLLN SLQQ YRQD QRDG SKSE DELD QAST PTDV RDID L |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | MPPH3; KIAK0002; Cyclin D2 |
Positive Sample: | NIH/3T3,Mouse spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Nucleus. |
Calculated MW: | 33kDa |
Observed MW: | 34kDa |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).
Purification Method: | Affinity purification |
Gene ID: | 894 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |