The CCND2 Polyclonal Antibody (CAB13284) is a valuable tool for researchers studying CCND2, a key regulator of cell cycle progression and proliferation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for various research applications, including Western blot analysis.CCND2, also known as Cyclin D2, plays a crucial role in controlling the G1/S transition in the cell cycle, thereby influencing cell growth and division. Dysregulation of CCND2 has been implicated in a variety of diseases, including cancer, making it a promising target for therapeutic interventions.
By utilizing the CCND2 Polyclonal Antibody, researchers can detect and analyze CCND2 expression in different cell types, providing valuable insights into its functions and potential therapeutic implications. This antibody is a valuable tool for studies in oncology, cell biology, and drug discovery aimed at targeting the cell cycle for therapeutic purposes.
Product Name:
Cyclin D2 Rabbit Polyclonal Antibody
SKU:
CAB13284
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-289 of human Cyclin D2 (NP_001750.1).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).
Purification Method:
Affinity purification
Gene ID:
894
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of RD, using Cyclin D2 antibody (CAB13284) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
