The CCND1 Polyclonal Antibody (CAB2708) is a valuable tool for researchers studying the CCND1 protein, a key regulator of cell cycle progression and proliferation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it an ideal choice for Western blotting applications. By binding to the CCND1 protein, this antibody facilitates accurate detection and analysis in a variety of cell types, making it indispensable for studies in cancer biology and cell cycle regulation.CCND1, also known as cyclin D1, is a pivotal player in driving cells through the G1 phase of the cell cycle, promoting cell division and growth.
Dysregulation of CCND1 has been implicated in various cancers, making it a promising target for therapeutic intervention. By elucidating the mechanisms by which CCND1 functions, researchers can gain valuable insights into tumor development and potentially identify novel strategies for cancer treatment. In conclusion, the CCND1 Polyclonal Antibody (CAB2708) is a valuable tool for investigating the role of CCND1 in cancer biology and cell cycle control, offering new avenues for cutting-edge research in the field.
Product Name:
Cyclin D1 Rabbit Polyclonal Antibody
SKU:
CAB2708
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-295 of human Cyclin D1 (NP_444284.1).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers.
Purification Method:
Affinity purification
Gene ID:
595
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cyclin D1 Rabbit pAb (CAB2708) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
