The CCNA1 Polyclonal Antibody (CAB14529) is a vital tool for researchers studying CCNA1, a protein involved in cell cycle regulation and cancer development. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting CCNA1 in human samples, making it ideal for use in Western blot applications. By targeting the CCNA1 protein, researchers can accurately analyze and study the role of CCNA1 in various cellular processes and diseases, such as cancer.CCNA1, also known as cyclin-A1, is crucial for controlling the progression of cells through the cell cycle and ensuring proper cell division.
Dysregulation of CCNA1 has been linked to the development and progression of various types of cancer, making it a promising target for cancer research and therapy development. By understanding the function and regulation of CCNA1, researchers can gain insights into the mechanisms underlying cancer growth and potentially identify new therapeutic strategies for combating cancer.
Product Name:
Cyclin A1 Rabbit Polyclonal Antibody
SKU:
CAB14529
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human CCNA1 (NP_001104515.1).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8900
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cyclin A1 Rabbit pAb (CAB14529) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
