The CCM2 Polyclonal Antibody (CAB6544) is a valuable tool for researchers studying the CCM2 protein, which plays a key role in the development of cerebral cavernous malformations (CCMs), a vascular disorder characterized by abnormal clusters of blood vessels in the brain. This antibody, raised in rabbits, is highly specific for CCM2 and has been validated for use in various applications, including Western blot and immunofluorescence.CCM2 is a crucial component of the CCM signaling pathway, which regulates vascular integrity and angiogenesis. Mutations in the CCM2 gene are associated with the development of CCMs, making it a promising target for therapeutic interventions.
By using the CCM2 Polyclonal Antibody, researchers can investigate the expression and localization of CCM2 in different cell types and tissues, providing insights into the underlying mechanisms of CCM formation and progression.Overall, the CCM2 Polyclonal Antibody is an essential tool for advancing our understanding of CCMs and developing targeted therapies for this debilitating vascular disorder. Its high specificity and reliability make it a valuable asset for researchers working in the fields of vascular biology, neurology, and genetic diseases.
Product Name:
CCM2 Rabbit Polyclonal Antibody
SKU:
CAB6544
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CCM2 (NP_113631.1).
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
83605
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from MCF7 cells, using CCM2 Rabbit pAb (CAB6544) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
