CCM2 Rabbit Polyclonal Antibody (CAB6544)
- SKU:
- CAB6544
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | CCM2 Rabbit Polyclonal Antibody |
SKU: | CAB6544 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CCM2 (NP_113631.1). |
Sequence: | MEEE GKKG KKPG IVSP FKRV FLKG EKSR DKKA HEKV TERR PLHT VVLS LPER VEPD RLLS DYIE KEVK YLGQ LTSI PGYL NPSS RTEI LHFI DNAK RAHQ LPGH LTQE HDAV LSLS AYNV KLAW RDGE DIIL RVPI HDIA AVSY VRDD AAHL VVLK TAQD PGIS PSQS LCAE SSRG LSAG SLSE SAVG PVEA CCLV ILAA ESKV AAEE LCCL LGQV FQVV YTES TIDF LDRA IFDG ASTP THHL SLHS DDSS TKVD IKET YEVE ASTF CFPE SVDV GGAS PHSK TISE SELS ASAT ELLQ |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | OSM; C7orf22; PP10187; CCM2 |
Positive Sample: | MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 49kDa |
Observed MW: | 55kDa |
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 83605 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |