The CCL8 Polyclonal Antibody (CAB6977) is a valuable tool for researchers studying CCL8, a chemokine involved in inflammation and immune responses. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to CCL8 protein, researchers can accurately detect and analyze its presence in various cell types, making it an essential component for studies in immunology and inflammatory diseases.CCL8, also known as monocyte chemoattractant protein-2 (MCP-2), plays a crucial role in recruiting monocytes and promoting inflammation at sites of infection or tissue damage.
Its involvement in immune cell migration and activation makes it a promising target for research into conditions such as inflammatory disorders, autoimmune diseases, and cancer. Understanding the function of CCL8 is vital for developing therapeutics that modulate immune responses and inflammation in these pathological contexts.
Product Name:
CCL8 Rabbit Polyclonal Antibody
SKU:
CAB6977
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-99 of human CCL8 (NP_005614.2).
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.
Purification Method:
Affinity purification
Gene ID:
6355
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human liver using CCL8 Rabbit pAb (CAB6977) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
