The CCL8 (MCP-2) Polyclonal Antibody (CAB10042) is a valuable tool for researchers investigating CCL8, a chemokine involved in immune cell recruitment and inflammation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting CCL8 in human samples, making it an ideal choice for use in Western blot applications. By binding to CCL8, this antibody enables the accurate detection and analysis of this important chemokine in various cell types, offering insights into its role in immunology and disease.CCL8, also known as Monocyte Chemoattractant Protein-2 (MCP-2), plays a crucial role in recruiting monocytes and other immune cells to sites of inflammation, contributing to the regulation of immune responses.
Its involvement in inflammatory processes makes it a key target for research on diseases such as cancer, autoimmune disorders, and inflammatory conditions. Investigating the function of CCL8 is essential for developing targeted therapies that modulate immune cell recruitment and inflammation in these pathological contexts, ultimately leading to improved treatment strategies.
Product Name:
CCL8/MCP-2 Polyclonal Antibody
SKU:
CAB24871
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-99 of human CCL8/MCP-2 (NP_005614.2).
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.
Purification Method:
Affinity purification
Gene ID:
6355
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with CCL8/MCP-2 using CCL8/MCP-2 Rabbit pAb(CAB24871) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
