RANTES Rabbit Polyclonal Antibody (CAB5630)
- SKU:
- CAB5630
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | RANTES Rabbit Polyclonal Antibody |
SKU: | CAB5630 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-91 of human CCL5/RANTES (NP_002976.2). |
Sequence: | MKVS AAAL AVIL IATA LCAP ASAS PYSS DTTP CCFA YIAR PLPR AHIK EYFY TSGK CSNP AVVF VTRK NRQV CANP EKKW VREY INSL EMS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta; CCL5/RANTES |
Positive Sample: | U-87MG,THP-1 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 10kDa |
Observed MW: | 13kDa |
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 6352 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |