The CCL4L1 Polyclonal Antibody (PACO06925) is a valuable tool for researchers studying the CCL4L1 protein, a member of the CC chemokine family involved in immune responses and inflammation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CCL4L1 protein, it allows for accurate detection and analysis in various cell types, making it a versatile tool for investigations in immunology and inflammatory conditions.CCL4L1, also known as macrophage inflammatory protein-1β, plays a crucial role in recruiting immune cells to sites of infection or injury, contributing to the body's defense mechanisms.
Its involvement in inflammatory processes suggests its potential as a therapeutic target for diseases such as rheumatoid arthritis, asthma, and other inflammatory disorders. By studying the function of CCL4L1, researchers can gain insights into immune system regulation and potentially develop novel treatment strategies for immune-related conditions.
Antibody Name:
CCL4L1 Antibody (PACO06925)
Antibody SKU:
PACO06925
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human MIP-1b.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of K562 cells using MIP-1b Polyclonal Antibody.
Western Blot analysis of K562 cells using MIP-1b Polyclonal Antibody.
CCL4L1: Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. Belongs to the intercrine beta (chemokine CC) family. 10 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 17q12
NCBI Summary:
This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]
