The CCL4 Antibody (PAC032656) is a high-quality research tool designed for the detection and analysis of CCL4, a chemokine involved in immune responses and inflammatory processes. This polyclonal antibody, produced using state-of-the-art technology, shows high reactivity with human samples and is validated for Western blot applications.CCL4, also known as macrophage inflammatory protein-1 beta (MIP-1β), plays a crucial role in recruiting immune cells to sites of infection or tissue damage. Its involvement in inflammatory processes makes it a key target for studying various diseases, including autoimmune disorders, infectious diseases, and inflammatory conditions.
The CCL4 Antibody enables accurate detection and quantification of CCL4 protein levels in different cell types, making it an invaluable tool for immunology and inflammation research.By using the CCL4 Antibody, researchers can gain insights into the regulation of immune responses and inflammatory pathways, ultimately paving the way for the development of targeted therapies for conditions related to dysregulated immunity and inflammation. Stay ahead in your research with this reliable and specific antibody for studying the role of CCL4 in health and disease.
Antibody Name:
Ccl4 Antibody (PACO32656)
Antibody SKU:
PACO32656
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse C-C motif chemokine 4 protein (24-92AA)
Form:
Liquid
Storage Buffer:
Preservative: 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2
Purification Method:
>95%, Protein G purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO32656 at dilution of 1:100.
Background:
Monokine with inflammatory and chemokinetic properties.
CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:
Protein type:Secreted; Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide
Cellular Component: extracellular space; extracellular region
Molecular Function:identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding
Biological Process: leukocyte chemotaxis; response to toxin; immune response; positive regulation of calcium-mediated signaling; positive regulation of tumor necrosis factor production; inflammatory response; chemotaxis; positive regulation of calcium ion transport; positive regulation of vascular permeability
