The CCL3 Polyclonal Antibody (CAB7568) is a vital tool for researchers studying CCL3, a chemokine known for its role in immune responses and inflammation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CCL3 protein, this antibody allows for the precise detection and analysis of CCL3 levels in various cell types, making it a valuable asset for studies in immunology and cancer research.CCL3, also known as macrophage inflammatory protein-1 alpha (MIP-1α), is a crucial mediator of immune cell recruitment and activation in response to infection or injury.
Its involvement in inflammatory processes highlights its potential as a therapeutic target in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By investigating the function of CCL3, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new treatment strategies that target this chemokine.
Product Name:
CCL3 Rabbit Polyclonal Antibody
SKU:
CAB7568
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 24-92 of human CCL3 (NP_002974.1).
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.
Purification Method:
Affinity purification
Gene ID:
6348
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using CCL3 Rabbit pAb (CAB7568) at 1:1000 dilution.THP-1 cells were treated by LPS for 6 hours and Brefeldin A for 3 hours of stimulation.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
