The CCL21 Polyclonal Antibody (CAB1896) is a valuable tool for researchers studying CCL21, a chemokine involved in immune cell trafficking and inflammation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the CCL21 protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for experiments in immunology and inflammatory disease research.CCL21, also known as secondary lymphoid chemokine (SLC), plays a critical role in directing immune cell movement and promoting immune responses.
Its involvement in inflammatory processes makes it a promising target for investigations into diseases such as autoimmune conditions, infectious diseases, and cancer. Understanding the functions of CCL21 is essential for developing novel therapeutic strategies that manipulate immune cell behavior and improve outcomes for patients with these conditions.
Product Name:
CCL21 Rabbit Polyclonal Antibody
SKU:
CAB1896
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-134 of human CCL21 (NP_002980.1).
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
Purification Method:
Affinity purification
Gene ID:
6366
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of recombinant Human CCL21 Protein using CCL21 Rabbit pAb (CAB1896) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 100 ng/10 ng/1 ng per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
