CCL2/MCP-1 Polyclonal Antibody (CAB21991)
- SKU:
- CAB21991
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | CCL2/MCP-1 Polyclonal Antibody |
SKU: | CAB21991 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-99 of human CCL2/MCP-1 (NP_002973.1). |
Sequence: | LAQP DAIN APVT CCYN FTNR KISV QRLA SYRR ITSS KCPK EAVI FKTI VAKE ICAD PKQK WVQD SMDH LDKQ TQTP KT |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; CCL2/MCP-1 |
Positive Sample: | Recombinant Human CCL2/MCP-1 Protein |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 11kDa |
Observed MW: | 35-40kDa |
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.
Purification Method: | Affinity purification |
Gene ID: | 6347 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |