The CCL2 Polyclonal Antibody (PAC032652) is a valuable tool for researchers studying the role of CCL2 in immune regulation and inflammation. CCL2, also known as monocyte chemoattractant protein-1 (MCP-1), is a key chemokine involved in the recruitment of monocytes and other immune cells to sites of infection or injury.This antibody, raised in rabbits, is highly specific for human CCL2 and has been validated for use in Western blot applications. By binding to CCL2, researchers can effectively detect and analyze this important chemokine in a variety of cell types, making it an ideal choice for studies in immunology, inflammation, and disease research.
Understanding the role of CCL2 in the immune response is crucial for developing targeted therapies for conditions such as cancer, autoimmune disorders, and inflammatory diseases. By using the CCL2 Polyclonal Antibody, researchers can further explore the mechanisms by which CCL2 functions in the immune system, paving the way for new treatment strategies and potential drug targets.
Antibody Name:
Ccl2 Antibody (PACO32652)
Antibody SKU:
PACO32652
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse C-C motif chemokine 2 protein (24-96AA)
Immunofluorescent analysis of Hela cells using PACO32652 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Chemotactic factor that attracts monocytes, but not neutrophils.
Synonyms:
C-C motif chemokine 2 (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Platelet-derived growth factor-inducible protein JE) (Small-inducible cytokine A2), Ccl2, Je Mcp1 Scya2
UniProt Protein Function:
CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:
Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine
Biological Process: positive regulation of cell adhesion; positive regulation of leukocyte migration; positive regulation of collagen biosynthetic process; chemotaxis; positive regulation of synaptic transmission; positive regulation of cellular extravasation; regulation of cell shape; transforming growth factor beta receptor signaling pathway; positive regulation of cell-cell adhesion; response to wounding; angiogenesis; inflammatory response; lymphocyte chemotaxis; neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; cytoskeleton organization and biogenesis; positive regulation of tumor necrosis factor production; glial cell migration; macrophage chemotaxis; leukocyte migration during inflammatory response; cellular calcium ion homeostasis; negative regulation of angiogenesis; positive regulation of leukocyte mediated cytotoxicity; response to heat; eosinophil chemotaxis; immune response; positive regulation of endothelial cell proliferation; positive regulation of T cell activation; vascular endothelial growth factor receptor signaling pathway; positive regulation of nitric-oxide synthase biosynthetic process
NCBI Summary:
This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]
