The CCL15 Polyclonal Antibody (PAC017665) is a valuable tool for researchers studying CCL15, a chemokine involved in the recruitment of immune cells to sites of inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been specifically validated for use in applications such as Western blotting.CCL15, also known as leukotactin-1, plays a crucial role in regulating immune responses by promoting the migration of immune cells such as monocytes, T cells, and dendritic cells to areas of tissue damage or infection.
Its involvement in the inflammatory process makes it a key target for research in fields such as immunology and cancer biology.By detecting and analyzing CCL15 protein expression in various cell types, researchers can gain insights into the mechanisms underlying immune cell recruitment and potential therapeutic strategies for diseases characterized by excessive inflammation. The CCL15 Polyclonal Antibody offers a reliable tool for investigating the role of CCL15 in immune regulation and its implications for disease pathogenesis.
Antibody Name:
CCL15 Antibody (PACO17665)
Antibody SKU:
PACO17665
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human CCL15
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17665(CCL15 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene, chemokine (C-C motif) ligand 15, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene is chemotactic for T cells and monocytes and induces N-acetyl-beta-D-glucosaminidase release in monocytes. It induces changes in intracellular calcium concentration in monocytes and is thought to act through the CCR1 receptor. Read-through transcripts are expressed that include exons from the downstream cytokine gene, chemokine (C-C motif) ligand 14, and are represented as GeneID: 348249.
Synonyms:
Chemokine (C-C motif) ligand 15
UniProt Protein Function:
CCL15: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:
Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide
Biological Process: cellular calcium ion homeostasis; positive chemotaxis; cell-cell signaling; immune response; chemotaxis; signal transduction
NCBI Summary:
This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]
C-C motif chemokine 15; leukotactin 1; chemokine CC-2; new CC chemokine 3; small-inducible cytokine A15; macrophage inflammatory protein 5; small inducible cytokine subfamily A (Cys-Cys), member 15
UniProt Protein Name:
C-C motif chemokine 15
UniProt Synonym Protein Names:
Chemokine CC-2; HCC-2; Leukotactin-1; LKN-1; MIP-1 delta; Macrophage inflammatory protein 5; MIP-5; Mrp-2b; NCC-3; Small-inducible cytokine A15Cleaved into the following 3 chains:CCL15(22-92); CCL15(25-92); CCL15(29-92)
