CCL14 Antibody (PACO32636)
- SKU:
- PACO32636
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CCL14 Antibody (PACO32636)
The CCL14 Antibody (PAC032636) is a valuable tool for researchers studying CCL14, a chemokine that plays a role in inflammation and immune response regulation. This polyclonal antibody, produced in rabbits, is highly specific and reactive with human samples, making it an excellent choice for Western blot analysis. By binding to the CCL14 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential tool for immunology and inflammation research.CCL14, also known as human hemofiltrate CC chemokine 1 (HCC-1), is involved in recruitment and activation of immune cells, making it a key player in inflammatory processes.
Understanding the role of CCL14 in immune regulation is essential for gaining insights into disorders such as autoimmune diseases, inflammation-related conditions, and cancer. By studying CCL14 activity and expression levels, researchers can uncover potential therapeutic targets for treating these diseases and conditions.
| Antibody Name: | CCL14 Antibody (PACO32636) |
| Antibody SKU: | PACO32636 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human C-C motif chemokine 14 protein (20-93AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO32636 at dilution of 1:100. |
| Background: | Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. |
| Synonyms: | C-C motif chemokine 14 (Chemokine CC-1/CC-3) (HCC-1/HCC-3) (HCC-1(1-74)) (NCC-2) (Small-inducible cytokine A14) [Cleaved into: HCC-1(3-74); HCC-1(4-74); HCC-1(9-74)], CCL14, NCC2 SCYA14 |
| UniProt Protein Function: | CCL14: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted Chromosomal Location of Human Ortholog: 17q12 Cellular Component: extracellular space Molecular Function:chemokine activity Biological Process: cellular calcium ion homeostasis; positive regulation of cell proliferation; immune response |
| NCBI Summary: | This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q16627 |
| NCBI GenInfo Identifier: | 14589959 |
| NCBI Gene ID: | 6358 |
| NCBI Accession: | NP_116738.1 |
| UniProt Secondary Accession: | Q16627,Q13954, E1P649, E1P650, |
| UniProt Related Accession: | Q16627 |
| Molecular Weight: | ~9.5 kDa |
| NCBI Full Name: | C-C motif chemokine 14 isoform 2 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 14 |
| NCBI Official Symbol: | CCL14Â Â |
| NCBI Official Synonym Symbols: | CC-1; CC-3; CKB1; MCIF; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYL2; SCYA14; HCC-1(1-74); HCC-1/HCC-3Â Â |
| NCBI Protein Information: | C-C motif chemokine 14 |
| UniProt Protein Name: | C-C motif chemokine 14 |
| UniProt Synonym Protein Names: | Chemokine CC-1/CC-3; HCC-1/HCC-3 |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | CCL14Â Â |
| UniProt Entry Name: | CCL14_HUMAN |
| ELISA Kits |
| Human CCL14 / HCC-1 ELISA Kit |
| Human CCL14 (Chemokine C-C-Motif Ligand 14) CLIA Kit (HUES00449) |
| Human CCL14 (Chemokine C-C-Motif Ligand 14) ELISA Kit (HUES01851) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Human CCL14 / HCC-1 ELISA Kit
Human Chemokine C-C-Motif Ligand 14 (CCL14) ELISA Kit
