CCL13 Antibody (PACO14205)
- SKU:
- PACO14205
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CCL13 Antibody (PACO14205)
The CCL13 Polyclonal Antibody (PACO14205) is a valuable tool for researchers studying CCL13, a chemokine involved in inflammatory responses and immune cell recruitment. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting.CCL13, also known as monocyte chemoattractant protein 4 (MCP-4), plays a crucial role in regulating the migration of monocytes, eosinophils, and lymphocytes to sites of inflammation. Its involvement in immune cell recruitment makes it a key player in diseases such as asthma, allergic reactions, and autoimmune disorders.
By targeting CCL13, researchers can gain insight into the mechanisms underlying these conditions and potentially develop new therapeutic strategies.Overall, the CCL13 Polyclonal Antibody is a reliable tool for investigating the functions of CCL13 in immune responses and inflammatory diseases, with the potential to advance our understanding of these conditions and guide the development of targeted treatments.
| Antibody Name: | CCL13 Antibody (PACO14205) |
| Antibody SKU: | PACO14205 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human CCL13 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: 293T cells, Primary antibody: PACO14205(CCL13 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
| Background: | This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. |
| Synonyms: | chemokine (C-C motif) ligand 13 |
| UniProt Protein Function: | CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine; Secreted Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: extracellular space Molecular Function:chemokine activity; receptor binding Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; cytoskeleton organization and biogenesis; immune response; signal transduction; inflammatory response; chemotaxis |
| NCBI Summary: | This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014] |
| UniProt Code: | Q99616 |
| NCBI GenInfo Identifier: | 3024128 |
| NCBI Gene ID: | 6357 |
| NCBI Accession: | Q99616.1 |
| UniProt Related Accession: | Q99616 |
| Molecular Weight: | |
| NCBI Full Name: | C-C motif chemokine 13 |
| NCBI Synonym Full Names: | C-C motif chemokine ligand 13 |
| NCBI Official Symbol: | CCL13Â Â |
| NCBI Official Synonym Symbols: | NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13Â Â |
| NCBI Protein Information: | C-C motif chemokine 13 |
| UniProt Protein Name: | C-C motif chemokine 13 |
| UniProt Synonym Protein Names: | CK-beta-10; Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; MCP-4; NCC-1; Small-inducible cytokine A13Cleaved into the following 3 chains:C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain |
| Protein Family: | Meiotic coiled-coil protein |
| UniProt Gene Name: | CCL13Â Â |
| UniProt Entry Name: | CCL13_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
CCL13 Antibody (PACO14206)
CCL13 Antibody (PACO17662)
CCL13 Antibody (PACO50134)
Human MCP4 protein / CCL13 ELISA Kit
Dog C-C motif chemokine 13 (CCL13) ELISA Kit (CNEB0063)
Human C-C motif chemokine 13 (CCL13) ELISA Kit (HUEB0492)
Human MCP-4/CCL13 (Monocyte Chemotactic Protein 4) ELISA Kit (HUES02239)
