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Ccl12 Antibody (PACO32664)

SKU:
PACO32664
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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Ccl12 Antibody (PACO32664)

The CCL12 Polyclonal Antibody (PAC032664) is a valuable tool for researchers studying CCL12, a chemokine protein involved in inflammation and immune response. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding specifically to the CCL12 protein, this antibody allows for the accurate detection and analysis of CCL12 in different cell types, making it an excellent choice for studies in immunology and inflammatory diseases.CCL12, also known as monocyte chemoattractant protein-5 (MCP-5), plays a crucial role in recruiting immune cells to sites of infection or injury, thereby promoting inflammation and immune defense mechanisms.

Dysregulation of CCL12 has been implicated in various inflammatory conditions, making it a promising target for research into diseases such as arthritis, asthma, and atherosclerosis. Understanding the function and regulation of CCL12 is essential for developing targeted therapies that modulate the immune response in these pathological contexts.

Antibody Name:Ccl12 Antibody (PACO32664)
Antibody SKU:PACO32664
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse C-C motif chemokine 12 ptotein (23-104AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Synonyms:C-C motif chemokine 12 (MCP-1-related chemokine) (Monocyte chemoattractant protein 5) (Monocyte chemotactic protein 5) (MCP-5) (Small-inducible cytokine A12), Ccl12, Mcp5 Scya12
UniProt Protein Function:CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis; Secreted

Cellular Component: extracellular space; extracellular region; intracellular

Molecular Function:CCR2 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: cytokine and chemokine mediated signaling pathway; positive regulation of leukocyte migration; MAPKKK cascade; cytoskeleton organization and biogenesis; chemotaxis; macrophage chemotaxis; monocyte chemotaxis; regulation of cell shape; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; immune response; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; astrocyte cell migration

UniProt Code:Q62401
NCBI GenInfo Identifier:2493663
NCBI Gene ID:102641905
NCBI Accession:Q62401.1
UniProt Secondary Accession:Q62401,Q9QYD6,
Molecular Weight:11,659 Da
NCBI Full Name:C-C motif chemokine 12
NCBI Official Symbol:LOC102641905  
NCBI Protein Information:c-C motif chemokine 12-like
UniProt Protein Name:C-C motif chemokine 12
UniProt Synonym Protein Names:MCP-1-related chemokine; Monocyte chemoattractant protein 5; Monocyte chemotactic protein 5; MCP-5; Small-inducible cytokine A12
Protein Family:C-C motif chemokine
UniProt Gene Name:Ccl12  
UniProt Entry Name:CCL12_MOUSE

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