The CCDC8 Polyclonal Antibody (PAC047138) is a valuable tool for researchers studying CCDC8, a protein involved in various cellular processes, including cell growth and division. This antibody, generated using rabbits as hosts, exhibits high reactivity towards human samples and has been validated for use in Western blotting applications. By binding specifically to CCDC8, this antibody enables precise detection and analysis of the protein in a wide range of cell types, making it a versatile tool for studies in cell biology and cancer research.
CCDC8, also known as coiled-coil domain-containing protein 8, plays a crucial role in regulating cell proliferation and survival, making it a potential target for therapeutic interventions in diseases like cancer. Understanding the function and regulation of CCDC8 is essential for developing strategies to target this protein for the treatment of various cancers and other proliferative disorders. The CCDC8 Polyclonal Antibody provides researchers with a reliable tool to explore the role of CCDC8 in cellular processes and disease pathogenesis.
Immunofluorescent analysis of Hela cells using PACO47138 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Western Blot. Positive WB detected in: Mouse liver tissue. All lanes: CCDC8 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 60 kDa. Observed band size: 60 kDa.
Background:
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.
Synonyms:
Coiled-coil domain-containing protein 8, CCDC8
UniProt Protein Function:
CCDC8: Defects in CCDC8 are the cause of 3M syndrome type 3 (3M3). A disorder characterized by poor postnatal growth and distinctive facial features, including triangular facies, frontal bossing, fleshy tipped nose, and fleshy lips. Other features may include skeletal anomalies and prominent heels.Protein type: Unknown functionChromosomal Location of Human Ortholog: 19q13.32Cellular Component: centrosome; cytoplasm; plasma membraneBiological Process: regulation of mitosis; microtubule cytoskeleton organization and biogenesisDisease: Three M Syndrome 3
UniProt Protein Details:
NCBI Summary:
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011]
