The CCDC28B Polyclonal Antibody (PAC061177) is a valuable tool for researchers studying CCDC28B, a protein involved in cell division and proliferation. This antibody is produced in rabbits and specifically targets CCDC28B in human samples, making it ideal for use in Western blot applications. By binding to CCDC28B, researchers can accurately detect and analyze this protein in various cell types, supporting studies in cell biology, cancer research, and more.CCDC28B is a crucial player in the cell cycle, regulating processes like mitosis and cytokinesis.
Dysregulation of CCDC28B has been linked to abnormal cell division and can contribute to diseases like cancer. By studying the function of CCDC28B, researchers can gain insights into cell growth and division mechanisms, potentially leading to advancements in cancer treatment and other related fields.Overall, the CCDC28B Polyclonal Antibody is a reliable tool for investigating the role of CCDC28B in cellular processes, offering valuable insights into potential therapeutic targets for various diseases.
Antibody Name:
CCDC28B Antibody (PACO61177)
Antibody SKU:
PACO61177
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Coiled-coil domain-containing protein 28B protein (1-76AA)
IHC image of PACO61177 diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.
Synonyms:
Coiled-coil domain-containing protein 28B, CCDC28B
UniProt Protein Function:
CCDC28B: Involved in ciliogenesis. Interacts with BBS1, BBS2, BBS4, BBS5, BBS6, BBS7 AND BBS8Chromosomal Location of Human Ortholog: 1p36.11-p34.2Cellular Component: centrosome; cytoplasmMolecular Function: protein bindingBiological Process: cilium biogenesisDisease: Bardet-biedl Syndrome 1
UniProt Protein Details:
NCBI Summary:
The product of this gene localizes to centrosomes and basal bodies. The protein colocalizes with several proteins associated with Bardet-Biedl syndrome (BBS) and participates in the regulation of cilia development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
