The CCDC22 Polyclonal Antibody (PACO8224) is a valuable tool for researchers studying CCDC22, a protein involved in cell cycle regulation and DNA repair mechanisms. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the CCDC22 protein, allowing for precise detection and analysis in various cell types.CCDC22 plays a crucial role in maintaining genomic stability and proper cell division, making it a key player in preventing the development of genetic mutations and cancer.
Research on CCDC22 has implications for understanding the mechanisms underlying tumorigenesis and identifying potential therapeutic targets for cancer treatment.By utilizing the CCDC22 Polyclonal Antibody in their research, scientists can gain valuable insights into the functions of CCDC22 and its involvement in DNA repair pathways. This antibody is an essential tool for studies in cancer biology, genetics, and cell biology, providing researchers with the means to further our understanding of the molecular mechanisms that govern cell cycle progression and DNA integrity.
CCDC22: May be involved in X-linked syndromic mental retardation (PubMed:21826058). CCDC22 expression has been found to be down-regulated in a family with a phenotype consistent with X- linked syndromic mental retardation, and carrying variant Ala-17. In addition to intellectual disability, affected individuals have cardiac and skeletal abnormalities. Belongs to the CCDC22 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: Xp11.23Molecular Function: protein bindingBiological Process: cellular copper ion homeostasis; cytoplasmic sequestering of NF-kappaB; Golgi to plasma membrane transport; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]
