The CCDC106 Polyclonal Antibody (PAC021540) is a valuable tool for researchers studying the CCDC106 protein, which plays a role in cellular processes such as cell cycle regulation and DNA repair. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.CCDC106, also known as coiled-coil domain-containing protein 106, is involved in maintaining genomic stability and promoting proper cell division. Dysregulation of CCDC106 has been implicated in cancer development and progression, making it a promising target for cancer research.
By detecting and analyzing CCDC106 levels in various cell types, this antibody allows for further investigation into the molecular mechanisms underlying tumorigenesis and potential therapeutic strategies.For scientists studying DNA repair pathways, cell cycle regulation, and cancer biology, the CCDC106 Polyclonal Antibody is a valuable tool for advancing our understanding of these processes. Its high reactivity and specificity make it an essential reagent for experiments aimed at elucidating the function of CCDC106 in normal and disease states.
Antibody Name:
CCDC106 Antibody (PACO21540)
Antibody SKU:
PACO21540
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:1000
Species Reactivity:
Human
Immunogen:
Peptide sequence around aa.2~6 (N-D-R-S-S) derived from Human Coiled-coil domain-containing protein 106.
Form:
Liquid
Storage Buffer:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells using Coiled-coil domain-containing protein 106 antibody and the same antibody preincubated with blocking peptide.
Background:
CCDC106 promotes the degradation of p53 protein and inhibits its transactivity.
Synonyms:
CCDC106; ZNF581; HSU79303
UniProt Protein Function:
CCDC106: Promotes the degradation of p53/TP53 protein and inhibits its transactivity.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleusMolecular Function: protein binding
