Anti-CCDC106 Antibody (PACO15942)

Antibody Name:	CCDC106 Antibody (PACO15942)
Antibody SKU:	PACO15942
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human CCDC106

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15942(CCDC106 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15942(CCDC106 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).

Background:

The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.

Synonyms:

coiled-coil domain containing 106

UniProt Protein Function:	CCDC106: Promotes the degradation of p53/TP53 protein and inhibits its transactivity.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleusMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q9BWC9
NCBI GenInfo Identifier:	94536856
NCBI Gene ID:	29903
NCBI Accession:	NP_037433.2
UniProt Secondary Accession:	Q9BWC9,Q99786, B3KUF9, D3K183
UniProt Related Accession:	Q9BWC9
Molecular Weight:	32,032 Da
NCBI Full Name:	coiled-coil domain-containing protein 106
NCBI Synonym Full Names:	coiled-coil domain containing 106
NCBI Official Symbol:	CCDC106
NCBI Official Synonym Symbols:	ZNF581; HSU79303
NCBI Protein Information:	coiled-coil domain-containing protein 106; protein predicted by clone 23882
UniProt Protein Name:	Coiled-coil domain-containing protein 106
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:	CCDC106
UniProt Entry Name:	CC106_HUMAN

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)